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Have not received prior first-line systemic therapy for metastatic or unresectable locally advanced melanoma. Adequate bone marrow function, hepatic and renal function. Capable of giving signed informed consent. Mucosal or ocular melanoma. Diagnosis of immunodeficiency or Bir Mı Var Herhangi Belge sovabet active autoimmune disease that required systemic treatment in the past 2 years ie, with use of disease modifying agents, corticosteroids, or immunosuppressive drugs.
Clinically significant multiple or severe drug allergies, intolerance to topical corticosteroids, or severe post-treatment hypersensitivity reactions including, but not limited to, erythema multiforme major, linear IgA dermatosis, toxic epidermal necrolysis, and exfoliative dermatitis.
Unable to swallow, retain, and absorb oral medications. Impairment of GI function or disease which may significantly alter the absorption of oral study intervention eg, uncontrolled nausea, vomiting or diarrhea, malabsorption syndrome, including malabsorption centabet Güven Sayfası secondary to prior GI surgery. Examples include transient ischemic attacks, cerebrovascular accidents, hemodynamically significant ie, massive or sub-massive deep vein thrombosis or pulmonary emboli.
History or current evidence of RVO or current centabet Güven Sayfası factors for RVO eg, uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or hypercoagulability syndromes Concurrent neuromuscular disorder that is associated with the potential of elevated CK eg, inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal muscular atrophy.
Current noninfectious pneumonitis or history of noninfectious pneumonitis requiring steroids, or history of radiation pnuemonitis Evidence of HBV or HCV infection. Known history of a positive test for HIV or known AIDS. Participants with prior or current symptomatic brain metastasis, leptomeningeal disease or other active CNS metastases. Participants with a history of other curatively treated cancers must be reviewed with the sponsor or designee prior to entering the study.
Known sensitivity or contraindication to any component of study intervention encorafenib, binimetinib and pembrolizumabor their excipients. Pregnant, confirmed by a positive β-hCG laboratory test centabet Güven Sayfası, or is breastfeeding lactating. Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members. Contacts and Locations.
Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. gov identifier NCT number : NCT Layout table for location contacts Contact: Pfizer CT. gov Call Center ClinicalTrials. of Pharmaceutical Services Drug Recruiting Los Angeles, California, United States, Ronald Reagan UCLA Medical Center, Drug Information Center, Dept.
Recruiting Farmington Hills, Michigan, United States, Michigan Health Professionals Recruiting Farmington Hills, Michigan, United States, United States, Montana St. Vincent Healthcare Recruiting Billings, Montana, United States, St. Luke's Health Baylor College of Medicine Medical Center Not yet recruiting Houston, Texas, United States, Harris Health System - Ben Taub Hospital Not yet recruiting Houston, Texas, United States, Harris Health System - Smith Clinic Not yet recruiting Houston, Texas, United States, Dan Brown O.
A Recruiting Viedma, RÍO Negro, Argentina, Instituto de Oncologia de Rosario Recruiting Rosario, Santa FE, Argentina, SKZE Austria Universitätsklinikum St. Pölten Recruiting St.
Recruiting Thessaloniki, Kentrikí Makedonía, Greece, 22 Hungary Pécsi Tudományegyetem Klinikai Központ Recruiting Pécs, Baranya, Hungary, Semmelweis Egyetem Recruiting Budapest, Hungary, Orszagos Onkologiai Intezet Recruiting Budapest, Hungary, Debreceni Egyetem Klinikai Kozpont Recruiting Debrecen, Hungary, Szent-Gyorgyi Albert Klinikai Kozpont Recruiting Szeged, Hungary, Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház Recruiting Szolnok, Hungary, Israel Ha'emek Medical Center.
Recruiting Afula, Hatsafon, Israel, Soroka University Medical Center Recruiting Be'er-Sheva, Israel, Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem Recruiting Jerusalem, Israel, Rabin Medical Center, Beilinson Hospital Recruiting Petah Tikva, Israel, The Chaim Sheba Medical Center Recruiting Tel Hashomer, Israel, Tel Aviv Sourasky Medical Center Recruiting Tel-Aviv, Israel, Italy Azienda Sanitaria Universitaria Friuli Centrale Centabet Güven Sayfası Udine, Friuli Venezia Giulia, Italy, Fondazione IRCCS Istituto Nazionale dei Tumori Recruiting Milano, MI, Italy, Istituto Dermopatico dell'Immacolata IDI-IRCCS Recruiting Roma, RM, Italy, A.
Policlinico "Le Scotte" Recruiting Siena, SI, Italy, Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia Recruiting Candiolo, Torino, Italy, Istituto Tumori Giovanni Paolo II Recruiting Bari, Italy, IRCCS Ospedale Policlinico San Martino Recruiting Genova, Italy, Istituto Europeo di Oncologia IRCCS Recruiting Milano, Italy, Istituto Nazionale Tumori IRCCS "Fondazione G.
Pascale" Recruiting Napoli, Italy, Istituto Oncologico Veneto IOV - IRCCS Recruiting Padova, Italy, AO di Perugia - Ospedale S. Maria della Misericordia, S. C Oncologia Medica Recruiting Perugia, Italy, Istituto Nazionale Tumori Regina Elena Recruiting Roma, Italy, Mexico ONCARE Viaducto Nápoles Recruiting Benito Juárez, Ciudad DE México, Mexico, Preparaciones Oncológicas S.
Recruiting León, Guanajuato, Mexico, I Can Oncology Center S. Recruiting Monterrey, Nuevo LEÓN, Mexico, BRCR Global Mexico - CDMX Recruiting Ciudad de México, Mexico, El Cielo Medical Center RSB, S.
C Recruiting Puebla, Mexico, El Cielo Medical Center Recruiting Puebla, Mexico, New Zealand New Zealand Clinical Research Christchurch Recruiting Christchurch, Canterbury, New Zealand, Palmerston North Hospital Recruiting Palmerston North, Manawatu, New Zealand, Auckland City Hospital Recruiting Auckland, New Zealand, Norway Akershus Universitetssykehus Recruiting Lørenskog, Akershus, Apologise, betsortie Basketbol Kupon Seçenekleri Nelerdir something, Oslo universitetssykehus, Radiumhospitalet Recruiting Oslo, Norway, Poland Jagiellońskie Centrum Innowacji Sp.
Recruiting Krakow, Poland, Szpital Specjalistyczny im.
Se rendre au site GlenLudwika Rydygiera w Krakowie Sp. Recruiting Krakow, Poland, Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu Recruiting Poznan, Poland, Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy Recruiting Warszawa, Poland, Russian Federation Private Medical Institution "Euromedservice" Active, not recruiting Pushkin, Saint-petersburg, Russian Federation, Ars Medika Center, LLC Active, not recruiting Kaliningrad, Russian Federation BIH of Omsk Region "Clinical Oncological Dispensary" Active, not recruiting Omsk, Russian Federation, Eurocityclinic LLC Active, not recruiting St.
Petersburg, Russian Federation, Slovakia Fakultná nemocnica s poliklinikou F. Wipbet Satış Ortağı Hizmeti Banská Bystrica Recruiting Banska Bystrica, Slovakia, 17 Onkologicky ustav sv.
Alzbety, s. Recruiting Bratislava, Slovakia, 50 Narodny onkologicky ustav Recruiting Bratislava, Slovakia, 10 Vychodoslovensky onkologicky ustav, a. Recruiting Kosice, Slovakia, Nemocnica na okraji mesta, n.
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